Since the era of industrialization with various domain activities such as manufacturing, processing, production, and development, large quantities of water corresponding to the generation of wastewater are simultaneously utilized. Anything that taints water is unacceptable. Global crises are caused by anthropogenic factors alike discharge of untreated effluents into adjacent water bodies. Heavy metals (HMs) in wastewater, that is, arsenic, cadmium, lead, mercury, nickel, zinc, etc., are particularly a significant problem related to their occurrence. Although time-consuming as well as expensive multidisciplinary strategies are widely used in their confiscation, recent breakthroughs in bioflocculation have yielded promising results in the treatment of such contaminants. Bioflocculation exploit the compounds that are either derived from plant (e.g., Moringa oleifera proteins), animal (e.g., chitosan), or microorganism (e.g., γ-polyglutamic acid) sources possessing the natural ability to agglomerate desired smaller quantity components in the reminder of degradability. It is an obligation to mitigate the deteriorating toxic effects of HMs wastewater on the environment, aquatic ecosystems, and the human race completely. Furthermore, recycled wastewater can be used in other sectors of technological requirements, contributing to sustainable practices. The chapter is essentially concerned with the use of bioflocculants (BF) along their mechanism to remove HMs from wastewater. A representation shall be made of certain information stating compositions, standards, and treatment methods, together with other possibilities. Nevertheless, some or the other challenges still exist in the field of removal of HMs from wastewater. It also recommends future perspectives, value addition, and economic feasibility.