To more intuitively and accurately show the spatial relationship and seismic damage assessment analysis results of buried pipeline network in the actual geographical environment under the action of earthquake, this paper proposes a three-dimensional dynamic visualization simulation method of seismic response of buried pipeline network based on ArcGIS, VTK, Adobe After Effects software and python language. Firstly, ArcGIS is used to quickly extract the basic data of underground pipeline network, and then the three-dimensional visualization model of pipeline is established by VTK function library. Finally, the image sequence of visualization model is output by Adobe After Effects software and the time progress bar is set to realize the three-dimensional dynamic visualization of pipeline network. This method can show the change process of strain and failure state of each section of pipeline network under earthquake. The method is used to simulate the three-dimensional dynamic visualization of the buried gas pipeline network in a certain area of southwest China under the action of earthquake, and the visualization effect of the method is demonstrated. The simulation can provide support for the determination of the weak parts of the underground gas pipeline network and the investigation of earthquake disaster risk.