This study aims to determine the fatigue-sensitive members of the transmission tower-line system subjected to wind loads, and to provide a scientific basis for the subsequent accurate analysis of the win-induced fatigue damage and life of transmission line systems. A three-dimensional finite element model of the transmission tower-line system is established based on the actual project, the wind load is simulated based on the linear filtering method. Furthermore, the impact analyses of wind attack angle on fatigue-sensitive members of a transmission tower-line system are carried out. The results show that with the increase of the wind attack angle from 0° to 90°, the sensitive members change from the 6th and 10th segments to the 3rd segments. The main members in the 3rd and 10th segments and the upper chords of the middle and lower crossarms, are identified as key sensitive members to provide a basis for subsequent wind-induced fatigue damage evaluation and fatigue life prediction.