Excessive heavy metals (HMs) on agricultural lands pose a significant hazard to plant growth and development, leading to a decline in crop yield and productivity. Plants use diverse strategies to combat the presence of unwanted HMs. Recent research suggests that ethylene has multiple functions in plants, playing a critical role in several physiological processes as well as enhancing HM stress tolerance. The modulation of ethylene levels in plants, achieved through numerous strategies targeting either ethylene production or the ethylene-signaling pathway, has shown encouraging results in bolstering resistance to HM stress. This chapter encompasses multiple facets of ethylene’s involvement in plant responses to HM stress. It also explores the intricate interplay between ethylene and various other signaling molecules in the context of adverse HM stress conditions. Additionally, the chapter delves into various approaches for modifying ethylene’s actions to enhance HM tolerance. Given our present understanding of ethylene and its regulatory functions, there is a growing belief that optimizing endogenous levels of ethylene under HM stress conditions in plants holds great promise.