A strong and cost-effective structural design is essential in light of the increasing demands and costs faced by customers and professionals. Despite the extensive use of many structural systems to provide suitable designs, engineers may soon turn to the relatively untested framed tube and structural wall systems as the primary structural system to resist lateral seismic loads. In order to understand the distribution of seismic force, response spectrum analysis was the method of choice, and ETABS was the program of choice for both analyses and designs. The current research used ETABS software to compare the evaluation of a structural wall-framed system to that of a framed tube system. Both the structural wall-framed tube system and the framed tube system were subjected to earthquake and gravity loads, and the main purpose of the study was to analyze their stiffness, base shear, drift, and deflections. Relative to base shear, the analytical results showed that the structure’s dynamic reactivity was significantly reduced. Addition of structurally framed walls decreased base shear by 9.11% in the x-direction and 16.88% in the y-direction. Significant reductions in displacement, tale drift, and the structure’s fundamental period were also noted.