Hydrogen, with its unique physiochemical properties, presents distinct challenges for safety and risk management across its value chain. This chapter outlines a multidisciplinary framework for risk management tailored to hydrogen applications, emphasizing its use as a fuel in hydrogen refueling stations. A thorough examination of the social, economic, and environmental sustainability pillars forms the foundation for a proposed risk management framework. The chapter also addresses the limitations of current quantitative risk assessments due to a lack of hydrogen-specific data and emphasizes the need for advanced leakage detection systems and robust safety measures. The proposed framework provides a comprehensive approach to managing hydrogen-related risks, as the foundation of the following chapters.