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As clinical testing shifts from the centralized labs to the point-of-care (POC) applications, biosensors may offer quick and affordable instruments. The creation of biosensors requires conductive substances functionalized with the bioreceptors that are functional and stable for measurements under real-world circumstances. MXene-based nanomaterials offer the chemical, electrical, mechanical, and structural characteristics that qualify them for POC devices. In 2011, the intriguing new family of the 2D materials known as MXenes was found. Since then, MXenes have had a significant impact on a number of industries, including electronics, energy, and more recently, biotechnology, thanks to their special combination of qualities, which include tunable hydrophilicity, extreme electrical conductivity, high specific area, tunable chemical structure, and probable cytocompatibility. Their application as electrically charged biointerfaces in various biosensor configurations, which demonstrate exceptional analytical performance, is a classic example of the latter. To create ultrasensitive biosensors, MXene nanocomposites, in particular, can function as transducers, bioreceptors, or as amplification probes to convert molecular identification of biological target into the detectable signals. MXenes have gained substantial research attention for the biosensing applications owing to their unique structural features and effective large and specific surface area. This chapter details recent advances in the use of MXene based materials for electrochemical biosensing applications. In this chapter we have synergistically and systematically delineated the recent advancements and significant development in the MXene based composites for electrochemical (bio)sensing applications. This chapter highlights recent developments of MXene based electrochemical biosensors for the highly sensitive and selective detection of proteins, NGAL, oncomiRs, breast cancer biomarker, cholesterol, H2O2, glucose, uric acid, oral cancer biomarker (CYFRA 21-1), small molecules, carcinoembryonic antigen, prostate cancer biomarker, exosomes, ovarian specific antigen (CA-125), creatinine, CA15-3, BC biomarker BRCA1, glucose biomarker, lactate biomarker, exosomes, and microRNA-21 pertaining to the biomarkers recognition and clinical diagnostics.

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MXenes in Electrochemical Biosensing: Pioneering Sustainable Diagnostics

  • 章节

  • 发表日期：

    2025年

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  • Gokana Mohana Rani,
  • Chandra Sekhar Tekuri,
  • Madhusudan B. Kulkarni,
  • Hari Bandi,
  • Perugu Shyam,
  • Reddicherla Umapathi

摘要

As clinical testing shifts from the centralized labs to the point-of-care (POC) applications, biosensors may offer quick and affordable instruments. The creation of biosensors requires conductive substances functionalized with the bioreceptors that are functional and stable for measurements under real-world circumstances. MXene-based nanomaterials offer the chemical, electrical, mechanical, and structural characteristics that qualify them for POC devices. In 2011, the intriguing new family of the 2D materials known as MXenes was found. Since then, MXenes have had a significant impact on a number of industries, including electronics, energy, and more recently, biotechnology, thanks to their special combination of qualities, which include tunable hydrophilicity, extreme electrical conductivity, high specific area, tunable chemical structure, and probable cytocompatibility. Their application as electrically charged biointerfaces in various biosensor configurations, which demonstrate exceptional analytical performance, is a classic example of the latter. To create ultrasensitive biosensors, MXene nanocomposites, in particular, can function as transducers, bioreceptors, or as amplification probes to convert molecular identification of biological target into the detectable signals. MXenes have gained substantial research attention for the biosensing applications owing to their unique structural features and effective large and specific surface area. This chapter details recent advances in the use of MXene based materials for electrochemical biosensing applications. In this chapter we have synergistically and systematically delineated the recent advancements and significant development in the MXene based composites for electrochemical (bio)sensing applications. This chapter highlights recent developments of MXene based electrochemical biosensors for the highly sensitive and selective detection of proteins, NGAL, oncomiRs, breast cancer biomarker, cholesterol, H2O2, glucose, uric acid, oral cancer biomarker (CYFRA 21-1), small molecules, carcinoembryonic antigen, prostate cancer biomarker, exosomes, ovarian specific antigen (CA-125), creatinine, CA15-3, BC biomarker BRCA1, glucose biomarker, lactate biomarker, exosomes, and microRNA-21 pertaining to the biomarkers recognition and clinical diagnostics.