This chapter presents a comprehensive framework for designing and implementing developmentally appropriate activities that support holistic growth during infancy and the preschool years. Grounded in contemporary research and aligned with child development principles, it emphasizes the need to provide enriched, engaging, and age-appropriate experiences in home and early learning settings. The chapter begins with an overview of what constitutes developmentally appropriate practice and explores how specific activities can foster physical-motor, cognitive, socio-emotional, and language development. It includes distinct sections with tailored activities for newborns, infants (birth to 1 year), toddlers (1–3 years), and preschoolers (3–6 years). Special attention is given to storytelling, creativity, environmental learning, and building scientific temperament—critical yet often overlooked areas in early education. In addition to play-based learning, the chapter highlights the concept of school readiness, detailing practical strategies for fostering reading, writing, and numeracy skills in preparation for formal schooling. This resource-rich chapter is designed to inspire educators, caregivers, and parents with a curated starter kit of ideas, while encouraging innovation and contextual adaptation for each child's developmental journey.