Students frequently bear heavy backpacks, potentially leading to musculoskeletal pain. This study explored the ergonomic aspects of backpack weight, its impact on student posture and function, and the importance of balance in injury prevention. A survey of 107 participants utilized the Nordic Musculoskeletal Questionnaire (NMQ). Results revealed significant correlations between carrying frequency (p < 0.001), weight (p = 0.003), duration (p = 0.002), and method (p = 0.004) with musculoskeletal disorders (MSDs). However, BMI (p = 0.322) and activity level (p = 0.258) were not significant factors. The lower back, upper back, shoulders, and neck were commonly affected areas. Targeting treatments to these specific areas is essential. Lowering backpack weight may alleviate musculoskeletal discomfort among students. This study underscores the pressing need to address the issue of heavy backpacks and their impact on student health. By identifying significant correlations between various factors related to backpack usage and musculoskeletal disorders, it provides valuable insights for preventive measures. Educating students on proper backpack usage and encouraging them to carry lighter loads could mitigate the risk of developing chronic pain or discomfort. Moreover, the study highlights the importance of considering ergonomic factors in designing backpacks. Manufacturers and educational institutions could collaborate to develop backpacks that distribute weight more evenly and minimize strain on the body. Additionally, promoting regular breaks and exercises to relieve stress on muscles and joints while carrying backpacks could further enhance students’ overall well-being.