Resorbable composites have appeared fairly recently as a revolutionary concept of implantable devices, with the characteristics of restorability, biocompatibility, and no need for a second operation. They are mostly based on polymers such as PLA and PGA, combined with bioactive ceramics or other reinforcements to give mechanical strength, which can degrade the body. Preclinical translation investigations are necessary to assess these composites’ safety, effectiveness, and prospects for use in a wide range of biomedical purposes promoting orthopedic, dental, and cardiovascular implants. Continuing with the focus of this paper, the author examines clinical trials, regulatory issues, and perspectives on the application of resorbable composites, especially in tissue engineering and repair. Some of the areas of focus are the strategies used in material design, performance evaluation in vivo, and customization particular to a patient. By filling the gaps in clinical validation, this work enriches the line of research that advances resorbable composites as a foundation of contemporary implantology and provides the foundation for developing individualized and minimally invasive therapies.