Depending on the methods and systems of deposit development, technogenic disturbances of the geological environment have different effects on its pollution. Pyrite complex deposits of the Orenburg region, developed by open-pit mining, have a technogenic impact on the environment. The ores of these deposits are a natural concentration of toxic elements. The main agent that ensures the oxidation of elements, removes reaction products, regulates the migration process of heavy metals in the conditions of external waste rock dumps is water. The purpose of the study is to assess the impact of technogenesis on the hydrosphere conditions of the Eastern Orenburg region. As a result, it was concluded that there are periodic excesses of such indicators as iron, manganese, lead, zinc, oil products at the “Autumn” and “Summer” copper-pyrite deposits. The hydrochemical situation at the copper-pyrite deposits of the Dombarovsky industrial hub is generally satisfactory. Regular monitoring and implementation of new technologies and, in particular, the use of complex barriers are recommended.