Globally, abiotic stresses such as salt, drought, and severe temperatures have a major impact on agricultural output and food security. Researchers have investigated the possibility of plant growth-promoting rhizobacteria (PGPR) and nanoparticles (NPs) as novel strategies to lessen these impacts. This chapter summarizes the synergistic impacts of NPs and PGPR on agricultural crops under different abiotic stresses. We go over how NPs and PGPR work together to improve plant production, growth, and stress tolerance. The chapter also discusses the possible advantages and difficulties of incorporating PGPR and NPs into farming methods. We also discuss possible uses of this synergistic technique in sustainable agriculture as well as future research possibilities.