Closure of schools and colleges due to the COVID-19 pandemic has brought significant disruption to the educational systems worldwide. According to the UNESCO report, COVID-19 affected about 800 million students worldwide. This paper aims to study the impact of the COVID-19 pandemic among college students in Kerala, one of the states in India. Through this quantitative study, we investigate the impact of the COVID-19 pandemic on education matters, physical health, and financial matters for Kerala college students. For that, we sent an online questionnaire form via WhatsApp to college students, and 406 of them filled out the questionnaire. We analyzed the results with SPSS and Excel. Through this study, we concluded that, 62.31% of students have lost their concentration in studies (also P-value is < 0.05 in SPSS analysis), 42.11% of respondents have decreased their interaction with teachers, 45.06% of respondents have decreased their interaction among classmates, 50% of the students have become worse at time management during offline exams, 54.3% of respondents agreed that their interest in participating in extracurricular activities has reduced, and 66.9% of respondents agreed that their financial status is badly affected by the COVID-19 pandemic. In the case of physical matters, 73.89% of respondents revealed that they are affected by irregular sleep, and 45.97% of females are affected by irregularities in their menstrual cycles. Also, females are more affected by muscle pain (50.93%), breathing disorders (38.58%), cholesterol (12.65%), stroke (19.13%), fainting (23.45%), and blood pressure (19.13%) than males. Through SPSS analysis our study found that three components (food intake, concentration in studies, and felt exhausted after small walk) are more significant. i.e., association between gender and the physical health component is statistically significant, association between gender and the concentration in studies is statistically significant and association between UG-PG and food intake is statistically significant (P-value < 0.05). Overall, the pandemic of COVID-19 negatively impacted the education, physical health, and financial matters of college students greatly.