This chapter examines the mental health issues that single mothers in South Asia are facing. Single mothers face social stigma, financial difficulties, and emotional isolation in patriarchal societies, which increases their susceptibility to anxiety, depression, and enduring stress. Single mothers’ access to emotional and financial support is further restricted by cultural attitudes that frequently portray them as social outcasts. Their declining mental health is exacerbated by financial instability, a lack of legal protection, and the strain of being the only caregiver. Children of single mothers are also more likely to experience social exclusion, emotional distress, and academic difficulties. Professionals in mental health play a critical role in community support, advocacy, and counselling. Even though there are government welfare programs intended to help single mothers, administrative barriers and a lack of knowledge frequently keep them from getting the necessary benefits. The chapter emphasizes the necessity of social inclusion programs, financial aid reforms, and integrated mental health policies and the need for systemic interventions to enhance the quality of life for single mothers by comparing them to international best practices. To promote a more inclusive society, it is imperative to address deeply rooted gender biases and strengthen social support networks.