This chapter explores the interplay between land-based spirituality and climate adaptation strategies within the Khyeng Indigenous communities of the Chittagong Hill Tracts in Bangladesh. Anchored in deep cultural and ecological traditions, the Khyeng demonstrate resilience amidst the profound impacts of human-induced climate change. The findings highlight critical challenges, including disruptions to agricultural livelihoods, health crises during disasters, and economic vulnerabilities. Despite these adversities, the Khyeng sustain adaptive strategies rooted in their spiritual practices, such as rituals for environmental harmony, daily gratitude, and seasonal agricultural preparations. These cultural mechanisms are complemented by community-driven initiatives like disaster preparedness and advocacy for land rights, underscoring the necessity of integrating Indigenous knowledge into broader climate policies. This chapter underscores the interconnectedness of environmental, socio-economic, and cultural dimensions in fostering sustainable adaptation. By valuing the Khyeng\u2019s spiritual and ecological knowledge, policymakers can advance inclusive and resilient approaches to climate action, providing lessons applicable to global efforts in environmental justice and sustainability.