Rural regions host agriculture and related activities, which contribute significantly to the well-being of the Zimbabwean economy. Yet, a myriad of factors restricts these regions to a slow growth trajectory, affecting their economic resilience. This chapter explores strategies for enhancing the economic resilience of rural regions in Zimbabwe. The study adopts a multidisciplinary approach since rural economies are complex, and their challenges are intertwined. The main challenge is that rural economies are mainly based on rain-fed agriculture, with other economic activities like mining, basket weaving, blacksmithing, pottery and carpentry being small-scale in nature. This economic structure makes rural economies vulnerable to different shocks and stresses, including climate change, land redistribution and fluctuations in market prices. Although rural regions have maintained strong links with urban economies, the relationship is mostly parasitic, benefitting the latter. Economic diversification and social overhead investments are some of the sustainable pathways to resilience-building in Zimbabwe’s rural regions. Social overhead investments unlock the growth and development of rural economies through increased accessibility, improved rural-urban linkages and the emergence and growth of rural industries. Value-addition and beneficiation are also essential for the resilience of rural economies. However, substantial investments are required to establish rural industries that convert primary products into secondary and tertiary goods traded on the national, regional and international markets.