The Middle East is facing a critical crisis in its environmental, economic, and social development as the pressures of rapid urbanization, resource scarcity, and climate change intensify. This chapter explores how Public–Private Partnerships (PPPs) can serve as a strategic vehicle for advancing circular economy (CE) principles in the region. It presents a comprehensive framework that demonstrates how well-structured PPPs can foster circularity in waste, water, and energy systems, enabling sustainable development through collaborative governance, innovation, and financial models. Drawing from regional case studies—including waste management programs in the UAE, water reclamation initiatives, and renewable energy investments—the chapter evaluates both the potential and limitations of PPPs in transforming linear systems into circular regenerative models. Key enablers such as stakeholder engagement, regulatory policies, technological innovations, and financial incentives are critically examined. The chapter also highlights the barriers to implementation, including institutional inertia, fragmented governance, and weak enforcement mechanisms. A roadmap for future action is proposed, emphasizing the integration of policy frameworks, private sector investment, and community involvement to scale circular solutions. By bridging theory with practice, this chapter contributes a region-specific lens to the global discourse on circularity and PPPs, offering insights for policymakers, practitioners, and scholars aiming to design resilient and inclusive urban systems in the Middle East.