Peristalsis is a mechanism where sinusoidal waves move axially along the length of the tube or channel, propelling physiological fluid (also known as biofluid). Understanding how surface roughness affects the movement of physiological fluids is crucial for comprehending a number of issues pertaining to blood in coronary arteries. To evaluate the nature of peristaltic flow, the channel walls are assumed to be sinusoidally wavy. We examine the micropolar fluids governing equations without body force or couple effects. Stream functions, pressure gradient, flow rate, axial velocity, and spin velocity solutions under specified physical boundary conditions are calculated. The consequences of relevant properties that characterize the behavior of micropolar fluids, including surface roughness, coupling number, and micropolar parameter on peristaltic pumping, are investigated.