Photodynamic therapy (PDT) is increasingly recognized for treating disorders of the hair follicle and sebaceous glands, including acne vulgaris, rosacea, hidradenitis suppurativa, and alopecia. In moderate-to-severe acne, ALA-PDT effectively reduces sebum production, curtails Propionibacterium acnes colonization, and modulates inflammation, with shorter incubation times and lower ALA concentrations enhancing safety by reducing pain and hyperpigmentation. While less established for rosacea, PDT has shown promise in decreasing inflammatory lesions and controlling Demodex growth, although larger studies are needed. For early-stage hidradenitis suppurativa, PDT can reduce inflammation and bacterial colonization, but inconsistent outcomes and significant side effects, such as pain and swelling, limit its broader application. In alopecia, PDT remains experimental, with studies on alopecia areata suggesting potential hair regrowth through anti-inflammatory mechanisms, although it is not yet a standard treatment for hair loss.