This chapter provides a comprehensive review of adverse reaction management in photodynamic therapy (PDT), a rapidly growing treatment in dermatology, focusing on three primary approaches: 5-aminolevulinic acid photodynamic therapy (ALA-PDT), hemoporphyrin derivative photodynamic therapy (HpD-PDT), and hemoporphyrin monomethyl ether photodynamic therapy (HMME-PDT). It explores the mechanisms behind common adverse reactions such as pain, erythema, edema, and pigmentation changes, emphasizing strategies to improve patient comfort and treatment adherence. The chapter covers pain assessment scales, alleviation protocols, cooling techniques, and posttreatment light protection while stressing the importance of patient education andadjusting treatment parameters to minimize side effects. Ultimately, it aims to equip dermatologists with the knowledge needed to optimize PDT outcomes and ensure the safety and effectiveness of this therapy for dermatological conditions.

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Management of Adverse Reactions to Photodynamic Therapy

  • Yutong Yang,
  • Dixin Wang,
  • Bo Wang,
  • Xiuli Wang

摘要

This chapter provides a comprehensive review of adverse reaction management in photodynamic therapy (PDT), a rapidly growing treatment in dermatology, focusing on three primary approaches: 5-aminolevulinic acid photodynamic therapy (ALA-PDT), hemoporphyrin derivative photodynamic therapy (HpD-PDT), and hemoporphyrin monomethyl ether photodynamic therapy (HMME-PDT). It explores the mechanisms behind common adverse reactions such as pain, erythema, edema, and pigmentation changes, emphasizing strategies to improve patient comfort and treatment adherence. The chapter covers pain assessment scales, alleviation protocols, cooling techniques, and posttreatment light protection while stressing the importance of patient education andadjusting treatment parameters to minimize side effects. Ultimately, it aims to equip dermatologists with the knowledge needed to optimize PDT outcomes and ensure the safety and effectiveness of this therapy for dermatological conditions.