This research investigates the cultural factors influencing the acceptance of medication vending machines in university settings, presenting a comparative study between Koreans and Emiratis. Employing a comprehensive survey approach, our study identifies cultural dimensions such as religious beliefs, traditional medicine preferences, government regulations, social norms, and technological adoption trends as critical influencers on healthcare attitudes. Distinct priorities for each cultural group are uncovered, offering nuanced insights into factors impacting the acceptance of innovative healthcare technologies. Additionally, the study reveals varied acceptance rates for installing medication vending machines on university campuses, with Emiratis demonstrating higher overall acceptance (average score of 4.2 out of 5) compared to Koreans (average score of 3.88 out of 5). These findings provide valuable guidance for healthcare policymakers, practitioners, and technology developers navigating cultural diversity in the implementation of healthcare solutions.