Exoskeletons, as elements of personal protective equipment, have potential to reduce MSD, which is the most common work-related health problem in the European Union. Exoskeletons can contain soft and rigid structures for force transition. However, there is a lack of comprehensive comparative research, especially in terms of performance metrics. This study addresses this gap by undertaking a comparative analysis of two commercially available back-supporting exoskeletons tailored for industrial applications. The experimental design encompassed twelve distinct tasks, drawing inspiration from existing studies and focusing on typical logistic and production-related activities. Objective performance indicators such as execution time, the number of lifts, and distance walked were measured. Also subjective parameters were recorded, including the perceived task difficulty and discomfort. Despite the study’s limitation in terms of participant numbers, statistically significant differences in both performance and participant comfort and handling were identified. In conclusion, both exoskeletons demonstrated efficacy in supporting lifting tasks, with a preference for a rigid system evident in static bending scenarios. Notably, for tasks involving extensive walking, a soft system emerged as a potentially favorable choice.