Carpal tunnel syndrome is a common condition among dialysis nurses. It is assumed that the daily set-up and dismantling of dialysis machines is the cause of the high prevalence in this occupational group. The aim of this study is to investigate the suitability of inertial sensors for the quantitative analysis of wrist movements. Inertial sensors from Xsens (DOT sensors, Xsens Technologies B.V., Netherlands) are used for this purpose. To validate these sensors, a comparison is made with a measurement system based on the time-of-flight measurement of ultrasonic pulses (Zebris System, Zebris Medizintechnik, Isny/Tübingen, Germany). The DOT sensors and Zebris markers are attached to a goniometer to simulate the directions of movement of the wrist. The angular range of 0–90° is scanned in 5° increments for each direction of movement. The mean values of the angles are displayed as a scatter diagram with a regression graph. The degree of correlation between the measurement results of the two systems is determined using Pearson’s correlation coefficient (r). The linear regression shows a good fit with a coefficient of determination of R2 = 1. The calculated angles deviate on average by 0.4° for palmar flexion and dorsiflexion and by 0.6° for ulnar and radial abduction from the angles measured with the Zebris system. The angle measurements with the inertial sensors and the Zebris system provide very similar values, considering the small offset. Further studies are required to assess the accuracy of the sensors during dynamic movements.