To support the movement of hospital beds, motorized Bed Movers have been developed. They are attached to hospital beds and can be controlled using a joystick, a tiller, or from a standing platform. Depending on the control method, different muscular strains occur on the handler. Comparative studies on the reduction of strain through bed movers are still insufficient. This study investigates the change in muscular strain when using three different bed movers compared to manually pushing a hospital bed. For this purpose, ten nursing staff members moved a hospital bed manually and with the three bed movers over a test course in a hospital. The activity of four muscle groups is measured using surface electromyography and tested for differences with a one-way analysis of variance. Moving the hospital bed with bed movers leads to a reduction in muscle activity. The average activity across all recorded muscle groups decreases significantly compared to manual pushing by 54% with the joystick bed mover, 42% with the tiller bed mover, and 74% with the platform bed mover. The different control concepts lead to varying reductions in muscle activity and thus to different levels of strain reduction. This should be considered when procuring bed movers, especially if they are used, for example, as a rehabilitation measure for employees.