This study explores musculoskeletal symptoms and fatigue among pharmacists, aiming to apply ergonomic interventions to optimize their working environment and workflow. These efforts promote resilience in a supportive workplace, ensuring patient medication safety and improving pharmaceutical services. Implementing smart dispensing counters and automated dispensing cabinets aimed to reduce manual errors, physical workload, and enhance medication management processes. The study used the Nordic Musculoskeletal Questionnaire (NMQ) and the Copenhagen Burnout Inventory (CBI) to assess intervention effects. Results showed a significant reduction in pain prevalence from 81% to 68% and a 60% decrease in severe pain instances. The pharmacists’ work fatigue rate decreased from 52% to 43%, with notable resilience improvement. Integrating human factors engineering and ergonomic design minimized errors, enhanced operational efficiency, and fostered a safer, supportive workplace. These findings highlight the need for continuous ergonomic improvements to ensure patient safety and pharmacist well-being. Future research should include diverse samples and explore advanced technologies like AI for further optimization.