People live in a digital and intelligent age, but their bodies and minds are designed to live in the physical world. As new technologies become more integrated into people’s everyday lives, it has become more challenging for designers to design physical experiences in complex interactions. Therefore, exploring physicality in an age of digital and intelligence has become increasingly important. Technological mediation provides the basic interaction patterns as a theoretical framework in this study, which is applied to analyze and categorize the physical aspects of interaction systematically. In addition to a comprehensive analysis of physicality of interaction, aspects of physicality are discussed in relation to their support for various interaction patterns design. The aspects on physicality of interaction can generally be divided into three categories: physical basis, physical process and physical relation, covering 9 aspects. This study attempts to deepen the theoretical understanding of physicality. In the future, we will conduct more in-depth theoretical and practical exploration to develop the mechanism of physical research in design.