The seismic performance and structural response of buildings are crucial considerations in earthquake-prone regions. This research chapter focuses on the dynamic analysis of a G + 10 building located in an area susceptible to the devastating effects of earthquakes in the Turkey–Syria region. The study aims to evaluate the building's behavior and seismic performance under the specific conditions of a seismic event, considering critical factors that could potentially lead to structural failure. The research methodology begins with a comprehensive seismic hazard assessment. This assessment involves analyzing historical seismic data, studying geological surveys, and considering regional tectonic characteristics to estimate ground motion parameters. By understanding the potential for seismic activity in the region, more accurate predictions of earthquake-induced ground motions can be made. The G + 10 building under investigation is accurately modeled, taking into account its architectural and structural elements, material properties, and foundation conditions. This meticulous modeling ensures a realistic representation of the building's behavior under earthquake-induced loads. The structural analysis is conducted using dynamic analysis methods, such as response spectrum analysis or time history analysis, which are widely accepted techniques for evaluating the dynamic response of structures. To simulate the effects of seismic events, design earthquakes are selected based on their representative ground motion characteristics derived from the seismic hazard assessment. These earthquakes serve as input ground motions for the dynamic analysis. The selected ground motions are applied to the building model as dynamic loadings, representing the forces and accelerations experienced during the earthquake events. Through the dynamic analysis, the building’s response is evaluated in terms of displacements, accelerations, and member forces. This assessment helps identify critical locations within the structure that may be prone to excessive displacements or forces, indicating potential vulnerabilities or areas of concern. By understanding the areas of weakness, appropriate measures can be taken to mitigate the risks and improve the building's seismic performance. The findings from this research provide valuable insights into the structural response and seismic performance of the G + 10 building in the Turkey–Syria earthquake scenario. The identification of critical locations within the structure helps inform decision-making processes related to structural design, retrofitting strategies, and risk mitigation measures. Ultimately, this research contributes to the development of more resilient structures capable of withstanding the devastating effects of earthquakes, thus enhancing the safety and sustainability of buildings in earthquake-prone regions.