Intelligent biomaterials including shape memory materials, self-powered biomaterials, stimuli-responsive biomaterials, interactive biomaterials, and micro/nanorobots are expected to solve key scientific and clinical problems in disease diagnosis and treatment, tissue engineering, bioimaging, wearable biosensors, and so forth. In this chapter, the situation and potentials of intelligent biomaterials for clinical translations are discussed, and the main bottleneck problems are also highlighted. The trends of future intelligent biomaterials are outlooked, including the emerging 3D/4D-printing intelligent polymers, organoid biomaterials, and flexible devices. It is noteworthy that researchers have designed next-generation intelligent biomaterials to meet the huge and increasing need for clinical theranostic solutions. Among them, the integration of intelligent biomaterials with artificial intelligence will be a very important and promising part to provide more efficient and convenient means for discovery, development, and ultimate medical translation of innovative intelligent biomaterials.