In recent years, there has been a growing interest in exploring natural bioactive compounds for their potential health benefits, particularly in the domain of nutraceuticals. Among these, sulfides, polyphenols, and phytoestrogens have emerged as noteworthy candidates due to their diverse biological activities and implications for human well-being. In this chapter, an intensive effort has been made to explore and present a comprehensive information on sulfides, polyphenols, and phytoestrogens as nutraceuticals, delving into their origins, chemical characteristics, biosynthesis and medicinal effects in detail. The medicinal applications of sulfides, polyphenols, and phytoestrogens span a wide spectrum of health conditions, ranging from cardiovascular health and metabolic disorders to hormonal imbalances and cancer prevention. Integrating these compounds into dietary patterns, functional foods, and nutraceutical formulations holds promise for personalized interventions tailored to individual health needs and preferences. Future research directions include innovating novel delivery systems, elucidating mechanisms of action, and exploiting synergistic interactions among these compounds for enhanced therapeutic outcomes.