Copper nanomaterials (CuNMs) can provide a viable alternative to traditional copper bactericides, potentially lowering the growth process of resistance in bacteria. Consequently, this will decrease the rate at which copper builds up in soil and water, reducing the negative effects of copper application on the environment and human health. CuNMs are highly significant and extensively manufactured metal nanomaterials. Their superior conductivity sets them apart from other more stable metal nanomaterials. Moreover, copper is an essential micronutrient that is involved in a number of vital plant functions, such as protein metabolism, enzyme activity, photosynthesis, cell wall construction, mitochondrial respiration, and the reaction to oxidative stress. Although CuNMs have been created via chemical and physical processes, their potential as plant bactericides has yet to be investigated. As a crucial micronutrient for crop growth, CuNMs combined with agrochemicals as herbicides and fertilizers are gaining traction for agricultural use as alternatives to conventional forms. Also, they have been employed in agriculture as an important component of fungicides for combating plant diseases. Copper-based nanoparticles, developed recently, present new opportunities for crop protection with improved efficacy and lower toxicity when compared to bulk Cu formulations. This chapter provides an overview on applications of copper-based nanomaterials in crop production.