The book chapter explores the possibility of increasing the number of profitable sites by optimizing hydro turbine and pump blade design for a wide range of energy resources. Site-specific designs were developed using state-of-the-art design tools that require a quick and efficient structural analysis to reduce the processing time per design cycle. Static structural analyses were performed for varied numbers of stator/runner blades and turbine blade aspect ratios against blade and runner and blade tip thickness fractions. Static structural analysis in the design process refines and facilitates narrowing down to the optimal design. The process helps to obtain a comprehensive site-specific design in the much-needed renewable energy sector. The performance was investigated using both experimentation and simulation techniques. The study of power generation was attempted using the current model. Cavitation development showed vapor formation, especially at low-cavitation conditions.