Major depressive disorder (MDD) presents a significant challenge due to its severity and the limited effectiveness of conventional pharmacological treatments and psychotherapies for many patients. This underscores the need for alternative therapeutic approaches. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have emerged as promising noninvasive brain stimulation techniques that address these needs. This chapter systematically reviews the applications of various TMS and tDCS paradigms, including bilateral repeat TMS (rTMS), accelerated rTMS, deep TMS, priming rTMS, synchronized rTMS, intermittent theta-burst stimulation (iTBS), accelerated iTBS, continuous theta-burst stimulation (cTBS), bilateral TBS, magnetic seizure therapy, high-definition tDCS, and a comparison between rTMS and tDCS. By exploring these physical treatment modalities, the chapter highlights their potential in effectively managing MDD and offers insights into their respective roles in enhancing patient care.