Hydrogel lubricants are becoming more popular in biomedicine and may replace cartilage. Hydrogels’ water content, network moisture, and mechanical properties meet articular cartilage replacement criteria. To understand lubrication, the study examines natural articular cartilage’s complex properties. This discovery advances lubricants that mimic these qualities. The essay discusses advanced bio-inspired architectural methods for cartilage hydrogels. As shown by case studies and experiments, diverse network topologies increase strength. Tribological features can be addressed to strengthen hydrogel lubricants for biomedical applications using novel surface modification methods. A specific perspective is presented on the practical uses of synthetic joint materials and natural bone tissues. Hydrogels on surfaces and their integration into artificial joint materials or organic bone tissues are examined in the study. This article analyzes methods and challenges, making them useful in many biological situations. The essay examines current challenges from multiple perspectives and suggests opportunities for cartilage-inspired hydrogel lubricant research. Future biomechanics and technology material development research is advised. The article emphasizes hydrogel lubricants in biology.