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The present study explicates the impact of CeO2 doping on sol–gel derived bio-ceramic with nominal composition 46%SiO2-24.4%Na2O-26.9%CaO-2.6%P2O5 (mol%). Cerium was selected for doping because of its low toxicity and bacteriostatic qualities. The sample’s bioactivity was evaluated by immersing them in simulated body fluids at 37˚C while being constantly stirred. XRD was employed to determine the crystalline phases and cell culture and cytotoxic experiments have been conducted to verify that the materials are non-toxic. Furthermore, samples under cell culture conditions have demonstrated a high percentage of viable cells, suggesting that the environment is conducive to cell growth. XRD results showed that materials with high cerium concentrations reduce bioactivity by generating cerium phosphate on their surfaces rather than hydroxyapatite. Higher concentrations of cerium-containing samples that show maximum cell viability are shown to favor maximum protection against oxidative stress generated by hydrogen peroxide and more cerium-containing samples that show maximum cell viability are more likely to favor apoptosis.

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Distinctive Structural and Biological Aspects of Sol–Gel Derived Phosphosilicate-Based Bio-Ceramic Containing Cerium Oxide

  • 会议论文

  • 发表日期：

    2026年

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  • Rakhi,
  • Pardeep Kaur,
  • Sandeep Kaur

摘要

The present study explicates the impact of CeO2 doping on sol–gel derived bio-ceramic with nominal composition 46%SiO2-24.4%Na2O-26.9%CaO-2.6%P2O5 (mol%). Cerium was selected for doping because of its low toxicity and bacteriostatic qualities. The sample’s bioactivity was evaluated by immersing them in simulated body fluids at 37˚C while being constantly stirred. XRD was employed to determine the crystalline phases and cell culture and cytotoxic experiments have been conducted to verify that the materials are non-toxic. Furthermore, samples under cell culture conditions have demonstrated a high percentage of viable cells, suggesting that the environment is conducive to cell growth. XRD results showed that materials with high cerium concentrations reduce bioactivity by generating cerium phosphate on their surfaces rather than hydroxyapatite. Higher concentrations of cerium-containing samples that show maximum cell viability are shown to favor maximum protection against oxidative stress generated by hydrogen peroxide and more cerium-containing samples that show maximum cell viability are more likely to favor apoptosis.