The fast-laying interlocking brick (IB) system represents an innovative approach to efficient masonry construction. This study introduces a novel IB system characterized by exceptional mechanical performance due to the unique shear key and fast-laying capability owing to the mortarless construction methodology. The paper evaluates the hazard-resistant features of this system, beginning with an investigation into the in-plane cyclic performance of the IB wall. This examination, conducted through laboratory experimentation, quantifies the loading-carrying capacity, deformation capacity, and energy dissipation capability. Subsequently, shaking table tests are executed to analyse the response and damage modes of the IB wall under in-plane seismic loading. Numerical simulations are employed to compare the performance of this IB wall with that of conventional mortar-bonded concrete masonry unit (CMU) walls. This comprehensive study contributes insights into the mechanical properties and hazard-resistant capabilities of IB system, offering valuable information for its application in construction practices.