Drones, particularly rotor-based Unmanned Aerial Vehicles (UAVs), have become integral to precision agriculture, enabling efficient crop monitoring, spraying, and data collection. However, the aerodynamic interactions between drone-generated airflow and plant canopies remain a critical yet underexplored aspect influencing agricultural outcomes. This chapter investigates the dynamics of drone airflow—especially rotor-induced downwash—and its interaction with various crop structures. It focuses on how airflow intensity, angle, and turbulence affect canopy penetration, pesticide and nutrient deposition, and microclimate modification. The role of flight parameters such as altitude, speed, and tilt angle in shaping airflow behavior and their impact on crop morphology, stress responses, and yield formation is also examined. Additionally, environmental variables like wind speed, temperature, and crop height are analyzed to understand their modulation of drone-crop aerodynamic interactions. To support this analysis, the chapter integrates foundational principles of UAV aerodynamics—lift, drag, thrust, and weight—and examines how different UAV configurations (rotary-wing, fixed-wing, and hybrid designs) influence airflow characteristics. By linking aerodynamic behavior to real-world agricultural performance, this study offers practical guidance for optimizing drone-based operations, enhancing input delivery, minimizing crop stress, and promoting sustainable farming practices.