In the ideal situation, the machining of any component is performed to meet the functional requirements of a part. However, due to the nature of the material removal mechanism (thermo-mechanical effects), it alters the microstructure and evolves crystallographic texture. Produced texture converts the isotropic to anisotropic properties of the material and thus affects the performance of the part. In order to control the microstructure alteration and evolution of texture during the end milling of Incoloy 925, biodegradable oil-based nanofluid under the MQL (minimum quantity lubrication) technique has been used in this study. Results show that cutting temperature and force have been reduced in the NMQL (nanofluid minimum quantity lubrication) environment compared to dry and pure oil-based MQL conditions. Consequently, the depth of microstructure alteration and texture evolution is controlled.