In high-density building environments, understanding the variation of interference effects with different building arrangement patterns is crucial for analyzing the stability of building structures. However, most of the past studies have focused on analyzing wind variation by considering a selected building arrangement or a selected city model. Therefore, in this study the variation of wind interference effect on different input wind velocities will be analyzed considering different high density building arrangements using Computational Fluid Dynamics (CFD). The Reynolds-Averaged Navier-Stokes (RANS) method utilizing the 2k − ω SST (Shear-Stress Transport) turbulence model will be used in the numerical simulation to observe wind flow variations. To consider different high density building arrangements, two building arrangement types named as Category-I and Category-II, were considered and each category was defined by two non-dimensional parameters λ and α. The Power law wind profile with reference height velocities (Vref) of 3 ms−1, 5 ms−1, 7 ms−1, 9 ms−1, and 11 ms−1 at a height of 10 m above ground, representing typical wind speeds in equatorial regions were used to analyze the sensitivity of interference effect on different Vref. In parametric study, normalized base moment was considered as an indicator of representing interference effect. Sensitivity analysis showed distinct variations in normalized base moment values for different Vref, with a maximum deviation of 6% for Category-I and 5% for Category-II. In Category-I, the maximum base moment occurred when λ equals to 0.25. For Category-II, the base moment was generally lower than isolated condition. However, stability concerns arise when the slope angle from central building to edge building is 45° to the horizontal (α = 0). These findings will be highly valuable for city designers, as they enable the optimization of building arrangements within urban environments to enhance building stability against wind interference effect. By carefully considering the heights of surrounding buildings and the critical angles formed between structures, designers can develop effective strategies to mitigate wind-induced forces. Additionally, this study concludes that the normalized base moment can serve as a reliable indicator of wind interference acting on central building, independent of the input Vref.