Wire electron beam additive manufacturing, also known as directed energy deposition-electron beam (DED-EB), provides unique advantages compared to other DED technologies. One of the main advantages is the easy and fast control of the beam by electromagnetic fields allowing the control of the energy input, the melt bead width, and the microstructure. Furthermore, the operation in a high vacuum prevents oxidation without the need of protective inert gases and leads to a high purity of the process environment. The high efficiency of the energy transfer from the energy source to the process is another benefit of DED-EB. This technology is especially competitive for materials with a high light reflectivity, which is a challenge for DED-LB (directed energy deposition-laser beam) due to extensive energy loss by reflection. Notable is also the availability of high beam energy. About 30 kW and more can be easily achieved with DED-EB while similar levels of high beam energy are very expensive for DED-LB. Such high energy input may be required for materials with high thermal conductivities or high melting temperatures. The aim of this chapter is to elaborate on these capabilities of DED-EB and to give examples.