The study of nautical charts depicting the Adriatic Sea during the Middle Ages and early modern period uncovered a diverse and intricate array of religious symbols. Religious symbols on nautical charts were predominantly rooted in Christianity, but Islamic motifs occasionally appeared, reflecting the historical coexistence and conflicts among Mediterranean states associated with these two religions. The Renaissance revival of interest in ancient cultural and scientific paradigms, including Greek and Roman religions and mythologies, further enriched the iconography found on nautical charts. These charts, while often serving decorative purposes, also conveyed nuanced messages to sailors and other users. This blending of religious iconography from various traditions reflected the layered cultural sedimentation and ongoing exchanges in the Adriatic region, embodying its complex historical and cultural dynamics.