Examining coping processes in Asian contexts is vital to supplement the scant literature focusing on stress management beyond Western paradigms. The present study utilised a person-centered approach to investigate whether adolescents could be differentiated according to their coping styles in relation to academic and social stressors, as well as the relationships of these profiles with key determinants of school functioning, such as trait anxiety, school resilience and self-compassion. The analytic sample consisted of 712 secondary school students in Singapore. The results of cluster analysis conducted on the students’ survey responses yielded four distinctive clusters of coping profiles that were consistent across academic and social stressors: (1) Passive Coping, (2) Active Coping, (3) Relational Coping, and (4) Isolated Coping. Active and relational coping profiles were found to be more adaptive in relation to the outcomes examined in the study.