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The development of multifunctional NanoMaterials (NM) and devices for biomedical applications has garnered significant attention due to their potential to revolutionize healthcare. This study synthesizes and characterizes novel NM with specific properties for targeted drug delivery, imaging, and biosensing. Using a bottom-up approach, we designed and fabricated nanocomposites (NC) made of biocompatible polymers, metallic nanoparticles (NPs), and quantum dots, exhibiting unique optical, magnetic, and electronic characteristics. These NCs were functionalized with specific ligands to facilitate active targeting of cancer cells and pathogens. Furthermore, we developed microfluidic devices to efficiently capture and analyze circulating tumor cells (CTCs) using the synthesized NM. The performance of these NM and devices was evaluated both in vitro and in vivo, demonstrating enhanced drug delivery efficiency, high-resolution imaging, and sensitive biosensing capabilities. This chapter addresses the biocompatibility and long-term stability of the NM under physiological conditions. It highlights that these multifunctional NM and devices are promising for advancing personalized medicine, early diagnosis, and targeted therapy. Additionally, it offers a comprehensive understanding of the design principles and potential applications of multifunctional NM in the biomedical field, paving the way for future research and clinical translation.

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Multifunctional NM: Integrating Optical, Thermal, and Electrical Properties for Biomedical Devices

  • 章节

  • 发表日期：

    2026年

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  • S. Rahila,
  • M. Nishanthi,
  • A. Priyadharshini,
  • P. Manikandan,
  • H. Mohammed Ameen,
  • G. Ganesh,
  • M. Syed Muzammil

摘要

The development of multifunctional NanoMaterials (NM) and devices for biomedical applications has garnered significant attention due to their potential to revolutionize healthcare. This study synthesizes and characterizes novel NM with specific properties for targeted drug delivery, imaging, and biosensing. Using a bottom-up approach, we designed and fabricated nanocomposites (NC) made of biocompatible polymers, metallic nanoparticles (NPs), and quantum dots, exhibiting unique optical, magnetic, and electronic characteristics. These NCs were functionalized with specific ligands to facilitate active targeting of cancer cells and pathogens. Furthermore, we developed microfluidic devices to efficiently capture and analyze circulating tumor cells (CTCs) using the synthesized NM. The performance of these NM and devices was evaluated both in vitro and in vivo, demonstrating enhanced drug delivery efficiency, high-resolution imaging, and sensitive biosensing capabilities. This chapter addresses the biocompatibility and long-term stability of the NM under physiological conditions. It highlights that these multifunctional NM and devices are promising for advancing personalized medicine, early diagnosis, and targeted therapy. Additionally, it offers a comprehensive understanding of the design principles and potential applications of multifunctional NM in the biomedical field, paving the way for future research and clinical translation.