Arsenic contamination continues to be hazardous to the natural environment and public health. Drinking water contamination, health effects, technology solutions, regulatory responses, food-borne arsenic, climate change implications, community engagement, multidisciplinary research, and global initiatives are some of the main areas of study. Arsenic is one of the most hazardous metalloids to human health. To protect the environment and public health, addressing arsenic contamination calls for interdisciplinary cooperation, community empowerment, and persistent international action. In general, consuming arsenic-contaminated water increased cancer risk in these areas. Urgent corrective and management actions are needed in order to supply the people of these impacted locations with safe drinking water. The review delves into the methodologies utilized for arsenic assessment, including laboratory analysis, field measurements, and remote-sensing techniques, emphasizing the importance of multidisciplinary approaches for comprehensive evaluation. This research review chapter underscores the importance of implementing mitigation strategies to address arsenic contamination effectively. Recommendations include improved water treatment infrastructure, adoption of agricultural best practices to minimize arsenic uptake in crops, and community education programs to raise awareness about arsenic related health risks. Drinking water is the major source of arsenic contamination which directly enters in the human body. Arsenic is known as carcinogen for human and animals. Chronic arsenic exposure can cause skin lesions, diabetes, lung, bladder, and kidney malignancies, cardiovascular disease, and developmental abnormalities. By providing a thorough assessment of arsenic contamination and its implications. This review paper offers the valuable insights for environmental agencies, public health officials, and policymakers to develop targeted interventions and safeguard the well-being of affected populations in the world. Ensuring safe drinking water and reducing arsenic exposure remain problems despite technological breakthroughs and regulatory measures, especially in communities that are more vulnerable.