As the urbanization progresses, need for sustainable, robust and cost-effective foundation for structure is desired. The feasibility of developing robust, cost-effective foundation may be developed by taking inspiration from nature. One of the deep foundations developed by taking inspiration from nature is snake-skin inspired piles. Based on the anisotropic behavior of snake surface, it has been observed that the friction reduces when snake scale moves in forward (cranial) and increases when it moves in backward (caudal) direction. In the present study, finite element numerical modeling has been performed, and EL-Centro earthquake excitation has been taken for the analysis. The analysis of the results suggests that snake skin inspired piles perform better in earthquake loading when compared to conventional piles. The results also demonstrate that bio-inspired piles require lesser cross-sectional area as compared to conventional piles to resist same amount of seismic load. The obtained results also provide an overview about the effect of asperities of snake texture on the Lateral displacement curve, lateral stresses of piles and maximum shear stresses of piles.