Targeting towards the sustainable goal, the emergence of manufacturing sand (M-sand) as an alternate for natural aggregates has unfolded new prospects for constructional practices in the world. Therefore, the investigation is focused to study the influence of M-Sand in the application of high strength concrete under impact loading. The reinforced concrete (RC) slabs were studied using M-sand (100%) with a concrete compressive strength of 80 MPa. The experimental results were presented in terms of failure pattern, impact force-time, and acceleration. It was observed that the scabbing of conventional concrete slab found to be 298 mm whereas the same was found to be 232.5 mm in case of concrete with M-sand, however, the mass found to be almost same as 2.3 kg for both the mixes. However, the resistance of slab with M-sand in terms of impact force (180 kN), contact time (61 ms) and plateau force (28 kN) found to be almost same to that of the conventional concrete slab. The peak acceleration in the conventional slab at 300 mm from impact location was found to be −254.82 g, whereas the same was found to be −398.12 g in case of slab with M-sand. Therefore, it is concluded that the manufactured sand is performed equivalent to the river sand in terms of measuring the impact force, contact time and plateau force. However, the concrete with manufactured sand performed better than river sand in terms of scabbing phenomena. Therefore, it was recommended to use manufactured sand as full replacement with river sand in the application of concrete with high strength.