This chapter explores the integration of Sustainable Enterprise Resource Planning (S-ERP) within the framework of Industry 4.0, highlighting its role in enhancing operational efficiency and promoting sustainability. Industry 4.0, driven by the Internet of Things (IoT) and Cyber-Physical Systems (CPS), aims to create intelligent, interconnected manufacturing and production systems. S-ERP extends these concepts by incorporating six key components: CPS, IoT, intelligence, supply chain, responsiveness, and volatile markets. Each component is crucial in achieving a holistic and sustainable approach to enterprise resource planning. The chapter discusses the technical implementation of S-ERP, focusing on data and process architectures. It details how vertical and horizontal data integration, centralized and decentralized data management, and real-time data processing contribute to efficient and sustainable operations. The process architecture includes dynamic planning, integrated end-to-end processes, human-machine interaction, location-independent control, process efficiency, and continuous improvement. A case study on GreenTech Industries demonstrates the practical application of S-ERP in transitioning to Industry 4.0. By leveraging IoT sensors, predictive maintenance, remote diagnostics, and advanced analytics, GreenTech achieved significant reductions in downtime, energy consumption, and waste while enhancing operational efficiency and customer satisfaction. The chapter concludes with a structured approach for organizations to move from Industry 3.0 to 4.0, emphasizing continuous improvement and stakeholder engagement.