In this chapter, pericardial disorders including pericardial effusion, cardiac tamponade, constrictive pericarditis (CP), and effusive constrictive pericarditis, etc. are illustrated using real-world case examples. Echocardiographic features that can differentiate pericardial effusion from pleural effusion and ascites are discussed. Pathophysiology of cardiac tamponade, constrictive pericarditis effusive constrictive pericarditis, and differentiation between constrictive pericarditis and restrictive cardiomyopathy using echocardiography are presented. Pertinent management issues with reference to current clinical practice guidelines are discussed.