Accompanied by accelerating globalization and digitization, e-commerce has become one of the important driving forces of global economic development. In the past decades, the rapid development of information and communication technologies (ICT) and the popularization of the Internet and mobile communication have provided technical support for the emergence of e-commerce. At the same time, the global trade and the economic integration have also provided important opportunities for the international e-commerce. In this context, the development of e-commerce in North America, Asia, Africa, Europe, and other regions presents different trends and characteristics. North America is one of the earliest regions in the development of international e-commerce, of which the market size and transaction volume are among the world’s top. The e-commerce market in Europe is relatively mature, but there are still differences between countries. The market in Asia is showing rapid growth and international e-commerce in Latin America, and the Middle East is also developing very rapidly, showing a diversified, geographically strong and high degree of digitization. The e-commerce market in Africa is relatively small, but the application of mobile payment and online shopping is gradually popularized. E-commerce between countries and around the world had become an important force to promote the prosperity of the global economy.