With the advancement of technology, the application of e-commerce has continuously increased, and its scale has expanded dramatically. Since the 2010s, the development of new technologies such as big data, cloud computing, the Internet of Things (IoT), artificial intelligence (AI), and blockchain has extended the e-commerce domain to numerous new engineering technology application scenarios, such as platform construction, transaction models, interoperability, and data sharing. These application scenarios have gradually formed a research frenzy centered around big data, cloud computing, IoT, AI, and blockchain, continuing to support the ongoing expansion of the e-commerce domain. This chapter mainly analyzes the cutting-edge research of relevant technologies, revealing the significant role of frontier technologies in the development of e-commerce.