Staphylococcus aureus is a concerning pathogen in both veterinary and public health due to its ability to cause a wide variety of infections. Staphylococcus aureus, which is resistant to methicillin, or known as methicillin-resistant Staphylococcus aureus (MRSA), has resistance to the majority of β-lactam antibiotics. Pigs are the reservoir hosts for MRSA, which poses risks to both animal and human health. The frequency of MRSA in pigs varies both systemically and regionally. Direct contact, contaminated environments, and human-to-animal transmission are the three ways that MRSA can infect pigs. Additionally, swine-associated MRSA strains may spread to humans through occupational exposure, food-borne transmission, and community interaction. According to genetic analysis, MRSA strains isolated from pigs are often linked to livestock-associated lineages, which are identified by specific genetic markers such as the absence of staphylococcal enterotoxins (SE) or Panton-Valentine Leukocidin (PVL) genes and the staphylococcal cassette chromosome mec (SCCmec) type IV or V. On the other hand, the possibility of genetic exchange between human-adapted MRSA strains and swine-associated bacteria highlights the significance of ongoing molecular characterization and surveillance programs.